2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101416
    Vanilpyruvic acid
    		98.28%
    Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
    Vanilpyruvic acid
  • HY-103638S
    3-Methoxytyramine-d4 hydrochloride
    		≥99.0%
    3-Methoxytyramine-d4 (hydrochloride) is the deuterium labeled 3-Methoxytyramine hydrochloride. 3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1).
    3-Methoxytyramine-d<sub>4</sub> hydrochloride
  • HY-G0018
    Norgestimate metabolite Norelgestromin
    		99.89%
    Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate) is a metabolite of Norgestimate (HY-W013172). Norgestimate metabolite Norelgestromin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norgestimate metabolite Norelgestromin
  • HY-103252S
    Monomethyl fumarate-d3
    		98.57%
    Monomethyl fumarate-d3 is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate is the primary metabolite of dimethyl fumarate.
    Monomethyl fumarate-d<sub>3</sub>
  • HY-118645S
    1'-Hydroxymidazolam-d4
    		99.12%
    1'-Hydroxymidazolam-d4 is the deuterium labeled 1'-Hydroxymidazolam. 1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam.
    1'-Hydroxymidazolam-d<sub>4</sub>
  • HY-G0007
    Omeprazole sulfone
    		98.92%
    Omeprazole sulfone is one of the major metabolites of Omeprazole (HY-B0113). Omeprazole sulfone is generated via sulfoxidation mediated by cytochrome P450 3A4 (CYP3A4).
    Omeprazole sulfone
  • HY-P3146A
    FTISADTSK acetate
    		99.66%
    FTISADTSK acetate is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM).
    FTISADTSK acetate
  • HY-66008
    N-Acetyl mesalazine
    		99.90%
    N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer.
    N-Acetyl mesalazine
  • HY-130189
    S-Phenylmercapturic acid
    		99.38%
    S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid
  • HY-W009538
    5'-Deoxy-5-fluorocytidine
    		99.91%
    5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine
  • HY-101397
    Allopurinol riboside
    		99.05%
    Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.
    Allopurinol riboside
  • HY-142122
    Imipramine N-oxide
    		99.90%
    Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant.
    Imipramine N-oxide
  • HY-N3059
    Pinostilbene
    		99.96%
    Pinostilbene (trans-Pinostilbene) is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells.
    Pinostilbene
  • HY-106714
    Clocortolone pivalate
    		99.93%
    Clocortolone pivalate is a synthetic glucocorticoid corticosteroid and corticosteroid ester. Clocortolone pivalate is indicated for seborrheic dermatitis, contact dermatitis, atopic dermatitis and psoriasis.
    Clocortolone pivalate
  • HY-135335
    3'-Hydroxy Repaglinide
    		98.09%
    3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
    3'-Hydroxy Repaglinide
  • HY-17530
    Aldicarb (sulfone)
    		99.80%
    Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb (sulfone)
  • HY-N3995
    5β-Dihydrocortisol
    		99.70%
    5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.
    5β-Dihydrocortisol
  • HY-100046
    Nordoxepin hydrochloride
    		99.94%
    Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression.
    Nordoxepin hydrochloride
  • HY-W053507
    m-Tolylacetic acid
    		99.93%
    m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid.
    m-Tolylacetic acid
  • HY-100085
    21-Desacetyldeflazacort
    		99.23%
    21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort
Cat. No. Product Name / Synonyms Application Reactivity